There's impactful news on the work front as Penny makes a big step toward pursuing a full-time acting career, and Sheldon is forced to take a vacation.
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Amy has amour on her mind when she talks Sheldon into a romantic Valentine's Day getaway to Napa Valley wine country. Back at home, Leonard and Penny make an emergency visit to the vet with Raj's dog.
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Leonard's purchase of a dining-room table for the apartment doesn't sit well with Sheldon, so much so that it forces him to reevaluate his life. Meanwhile, Bernadette isn't quite over the moon about Howard taking another trip to space.
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Things turn rocky between Sheldon and Wolowitz after a barrage of insults, and Bernadette steps in to mediate a peace. Meanwhile, Penny is offered a movie role that may prove embarrassing.
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While Sheldon and Howard continue their bonding, Sheldon's visit to see his mommy forces him to start addressing a new reality. The gang are subjected to a murder mystery party that leads them to speculate where they might be in 20 years.
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Raj wrestles with dating two women at the same time; Penny is offered a part in a trashy movie; and Sheldon can't decide between two gaming systems.
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